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Secondary Hyperparathyroidism: Pathophysiology and Treatment

From Department of Internal Medicine, University of Kansas School of Medicine, Wichita

Correspondence: Corresponding author: Wissam Saliba, MD, Department of Internal Medicine, University of Kansas School of Medicine, 505 North Rock Road, Apt #1436, Wichita, KS 67206 (E-mail: salibawissam{at}hotmail.com)

Secondary hyperparathyroidism is a frequently encountered problem in the management of patients with chronic kidney disease (CKD). Its pathophysiology is mainly due to hyperphosphatemia and vitamin D deficiency and resistance. This condition has a high impact on the mortality and morbidity of dialysis patients. Early diagnosis of secondary hyperparathyroidism is crucial in the management of patients with CKD. The treatment remains a challenge for patients and their clinicians. It should include a combination of dietary phosphorus restriction, phosphate binders, vitamin D analogues, and calcimimetics.

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